74 Mice exposed to cigarette smoke for 8 weeks and treated with hydrogen-rich pure water showed lower lung compliance, decreased levels of oxidative DNA damage markers such as phosphorylated histone H2AX and 8-hydroxy-20-deoxyguanosine, and lower lung senescence markers such as cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 1, and b-galactosidase
Key Takeaways No head-to-head trial exists
Chen, L., et al
With an IC 50 value of 2.62mM, compound 91 inhibited the AChE enzyme (Ohlendorf et al., 2012)
46 showed that a preserved responsiveness to the endothelium-dependent vasodilator acetylcholine, administered intracoronarily, is associated with a significantly lower incidence of cardiovascular events defined as a composite end point, including cardiovascular death, unstable angina, myocardial infarction, coronary revascularization, ischemic stroke and peripheral artery revascularization
& Cardioprotection of Canagliflozin, Dapagliflozin, and empagliflozin: Lessons from preclinical studies
